Design, synthesis, and osteogenic activity of daidzein analogs on human mesenchymal stem cells

…, S Elliott, ME Burow, BA Bunnell, G Wang

文献索引：Strong, Amy L.; Jiang, Quan; Zhang, Qiang; Zheng, Shilong; Boue, Stephen M.; Elliott, Steven; Burow, Matthew E.; Bunnell, Bruce A.; Wang, Guangdi ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 2 p. 143 - 148

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被引用次数: 13

摘要

Osteoporosis is caused by an overstimulation of osteoclast activity and the destruction of the bone extracellular matrix. Without the normal architecture, osteoblast cells are unable to rebuild phenotypically normal bone. Hormone replacement therapy with estrogen has been effective in increasing osteoblast activity but also has resulted in the increased incidence of breast and uterine cancer. In this study we designed and synthesized a series of daidzein ...