Tetrahedron

Pd-catalyzed Fukuyama cross-coupling of secondary organozinc reagents for the direct synthesis of unsymmetrical ketones

AH Cherney, SE Reisman

文献索引：Cherney, Alan H.; Reisman, Sarah E. Tetrahedron, 2014 , vol. 70, # 20 p. 3259 - 3265

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被引用次数: 15

摘要

Abstract The coupling of acyl electrophiles with organometallic reagents represents a convergent route toward complex and versatile ketone products. Despite the mild conditions and high functional group tolerance, the cross-coupling of carboxylic acid derivatives, such as thioesters, and secondary organometallic reagents is an underdeveloped transformation. Herein, we disclose a convenient and efficient protocol for the Pd-catalyzed Fukuyama ...