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Derivatives of 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil and 5-Benzyluracil. Synthesis and Biological Properties

K Dziewiszek, RF Schinazi, TC Chou…

文献索引:Dziewiszek; Schinazi; Chou; Su; Dzik; Rode; Watanabe Nucleosides and Nucleotides, 1994 , vol. 13, # 1-3 p. 77 - 94

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被引用次数: 7

摘要

Abstract A number of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) uracil and-cytosine nucleosides substituted at the 5 position with a nitrophenyl or nitrobenzyl group were synthesized from 5-phenyl-and 5-benzyluracil via condensation of the fluorinated sugar, followed by nitration. The corresponding amino analogues were also prepared by reduction of the nitro nucleosides. The uracil nucleosides were converted into the corresponding ...