Tetrahedron letters

A novel, highly efficient and selective desilylating method for trialkylsilyl ethers

ASY Lee, HC Yeh, JJ Shie

文献索引：Lee, Adam Shih-Yuan; Yeh, Hsiu-Chih; Shie, Jiun-Jie Tetrahedron Letters, 1998 , vol. 39, # 29 p. 5249 - 5252

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被引用次数: 43

摘要

A series of tert-butyldimethylsilyl, tert-butyldiphenylsilyl and triisopropylsilyl ethers are hydrolyzed to theirs corresponding alcohols in CBr 4CH 3OH (0.1 eq. 10mL) reaction system under refluxing condition. The chemoselectivity can be achieved between primary and secondary triisopropylsilyl ethers when more hindered 2-propanol is used instead of methanol.