Tetrahedron

A novel tert-butoxycarbonylation reagent: 1-tert-butoxy-2-tert-butoxycarbonyl-1, 2-dihydroisoquinoline (BBDI)

Y Saito, H Ouchi, H Takahata

文献索引：Saito, Yukako; Ouchi, Hidekazu; Takahata, Hiroki Tetrahedron, 2006 , vol. 62, # 50 p. 11599 - 11607

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被引用次数: 30

摘要

The use of 1-tert-butoxy-2-tert-butoxycarbonyl-1, 2-dihydroisoquinoline (BBDI) as a tert- butoxycarbonylation reagent for acidic proton-containing substrates such as phenols, aromatic and aliphatic amines hydrochlorides, and aromatic carboxylic acids in the absence of a base is described. The reactions proceed chemoselectively in high yield under mild conditions.