Bioorganic & medicinal chemistry letters

A new, efficient, and simple method for the one-pot synthesis of α-acetoxyphosphonates from aldehydes under solvent-free conditions

B Kaboudin, M Karimi

文献索引：Kaboudin, Babak; Karimi, Masoumeh Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5324 - 5327

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被引用次数: 41

摘要

A simple, efficient, and new method has been developed for the synthesis of α- acetoxyphosphonates from aldehydes through a one-pot reaction of aldehydes with diethylphosphite in the presence of acetic anhydride under solvent-free conditions using magnesium oxide. This method is easy, rapid, and high yielding for the one-pot synthesis of α-acetoxyphosphonates from aldehydes.