Orally absorbable cephalosporin antibiotics. 1. Structure-activity relationships of benzothienyl-and naphthylglycine derivatives of 7-aminodeacetoxycephalosporanic …

S Kukolja, SE Draheim, JL Pfeil…

文献索引：Kukolja; Draheim; Pfeil; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1886 - 1896

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被引用次数: 25

摘要

The reaction was carried out in trifluoroacetic acid at room temperature for 18 h and the protected 3-benzothiopheneglycine isolated in 88% yield. One advantage of this method is that the amino acid is isolated as the amino protected derivative which could be immediately used for acylation of 7-ADCA. 1C. Metalation Method. Several bicyclic or heteroaromatic compounds were metalated with lithium. n-Butyllithium was used for the replacement of ...