Tetrahedron Letters

Regioselective ring-opening of epoxides with amines using Zn (ClO 4) 2–Al 2 O 3 as a heterogeneous and recyclable catalyst

M Maheswara, KSVK Rao, JY Do

文献索引：Maheswara, Muchchintala; Rao, Kummari Subba Venkata Krishna; Do, Jung Yun Tetrahedron Letters, 2008 , vol. 49, # 11 p. 1795 - 1800

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被引用次数: 25

摘要

In this Letter, we have described a mild and efficient method for the nucleophilic ring-opening of epoxides with amines in the presence of heterogeneous catalyst zinc perchlorate–neutral alumina to afford the corresponding β-amino alcohols in excellent yields. It was observed in the absence of catalyst, the reaction did not proceed in dichloromethane even after prolonged reaction times (Scheme 1). In the presence of zinc perchlorate Zn(ClO 4 ) 2 without using alumina ...