Journal of heterocyclic chemistry

Pyrimidines. 7. A study of the chlorination of pyrimidines with phosphorus oxychloride in the presence of N, N??dimethylaniline

H Gershon, AT Grefig

文献索引：Gershon, Herman; Grefig, Anthony T. Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1161 - 1167

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被引用次数: 41

摘要

Abstract The chlorination of 6-trifluoromethyluracils by phosphorus oxychloride in the presence of N, N-dimethylaniline was studied and compared with results obtained with 6- methyluracils. 6-Trifluoromethyluracil and its 5-chloro analog afforded moderate yields of the di-and trichloropyrimidines, accompanied by good yields of the 2-N-methylanilino by- products, after a 3-hour reaction time. After 24 hours, the 2-N-methylanilinopyrimidines ...