Metabolism of the antitumor drug thiophosphamide in the rat

…, OS Anisimova, ZF Presnova, LA Kostryukova…

文献索引：Chistyakov, V. V.; Anisimova, O. S.; Presnova, Zh. F.; Kostryukova, L. A.; Chernov, V. A.; et al. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 10 p. 721 - 725 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 10 p. 1158 - 1162

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摘要

In this work we used a combination of methods of TLC and mass spectrometry, permitting sufficiently reliable establishment of the structure of the isolated products of metabolism. To facilitate the identification of the metabolites we made a preliminary study of the mass spectra of certain conversion products of I in hydrochloric acid solution.