Tetrahedron

One-pot synthesis of 2-aryl-3-alkoxycarbonyl chromones through a cascade Lewis acid-catalyzed aldehyde olefination/oxa-Michael addition/oxidation

N Wang, S Cai, C Zhou, P Lu, Y Wang

文献索引：Wang, Ningning; Cai, Shuying; Zhou, Chao; Lu, Ping; Wang, Yanguang Tetrahedron, 2013 , vol. 69, # 2 p. 647 - 652

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被引用次数: 4

摘要

2-Aryl-3-alkoxycarbonyl chromones were effectively constructed from aryl aldehydes and 3- (2-(methoxymethoxy) phenyl) propiolates via a cascade Lewis acid catalyzed phenol ether deprotection/aldehyde olefination/intramolecular oxa-Michael addition reaction, and a sequential oxidation. This four-step reaction could be conducted in one-pot with high atom efficiency.