Abstract We have developed a new strategy that uses the Kröhnke synthesis for the preparation of various substituted phenylpyridines in excellent yields (up to 88%). Starting with the appropriate commercially available acetophenone, a variety of phenylpyridines substituted by either electron-donating (ie methyl, methoxy) or-withdrawing groups (ie bromide, nitro) on the phenyl ring are obtained in a two-step synthesis. The corresponding ...
