3-Amino-pyrazolo [3, 4-d] pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead

…, N Dewdney, K Durkin, S Frauchiger, M Ghate…

文献索引：Soth, Michael; Abbot, Sarah; Abubakari, Allassan; Arora, Nidhi; Arzeno, Humberto; Billedeau, Roland; Dewdney, Nolan; Durkin, Kieran; Frauchiger, Sandra; Ghate, Manjiri; Goldstein, David M.; Hill, Ronald J.; Kuglstatter, Andreas; Li, Fujun; Loe, Brad; McCaleb, Kristen; McIntosh, Joel; Papp, Eva; Park, Jaehyeon; Stahl, Martin; Sung, Man-Ling; Suttman, Rebecca; Swinney, David C.; Weller, Paul; Wong, Brian; Zecic, Hasim; Gabriel, Tobias Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3452 - 3456

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被引用次数: 17

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile. ... We recently reported on our pyrimidinopyridone inhibitors, exemplified by 1 ( ...