Self??Assembling Ligands for Multivalent Nanoscale Heparin Binding

AC Rodrigo, A Barnard, J Cooper…

文献索引：Rodrigo, Ana C.; Barnard, Anna; Cooper, James; Smith, David K. Angewandte Chemie - International Edition, 2011 , vol. 50, # 20 p. 4675 - 4679

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被引用次数: 33

摘要

Heparin is a highly negatively charged sulfated polysaccharide with a heterogeneous mixture of diverse chains with different lengths that consist of repeating copolymers of 1–4 linked iduronic acid and glucosamine residues in a semirandom order (Scheme 1).[1] This polysaccharide regulates a variety of cellular processes, plays important roles in biological systems, and interacts with a wide range of protein targets.[2] Heparin is widely used as ...