Synthesis of Methylene-and Difluoromethylenephosphonate Analogues of Uridine-4-phosphate and 3-Deazauridine-4-phosphate

…, F Mirzaei, A Sharifi, SL Bearne

文献索引：Taylor, Scott D.; Mirzaei, Farzad; Sharifi, Ali; Bearne, Stephen L. Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9420 - 9430

全文：HTML全文

被引用次数: 14

摘要

Cytidine triphosphate synthetase (CTPS) catalyzes the formation of cytidine triphosphate from glutamine, uridine-5'-triphosphate (UTP), and adenosine-5'-triphosphate. Inhibitors of CTPS are of interest because of their potential as therapeutic agents. One approach to potent enzyme inhibitors is to use analogues of high energy intermediates formed during the reaction. The CTPS reaction proceeds via the high energy intermediate UTP-4-phosphate ...