Synthesis

Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2 (1H)-one

VL Alifanov, EV Babaev

文献索引：Alifanov, Vadim L.; Babaev, Eugene V. Synthesis, 2007 , # 2 p. 263 - 270

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被引用次数: 14

摘要

Abstract Stepwise conversion of pyrimidin-2 (1H)-one to 2-amino-5-aryloxazoles via oxazolo [3, 2-a] pyrimidinium salts is reported. The sequence involves,(i) regioselective N-alkylation of pyrimidone by phenacyl bromides,(ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)