The transition-metal-catalyzed transformation of inactivated CÀH bonds into CÀheteroatom and CÀC bonds has found synthetic utility in a number of total syntheses through the use of CÀH activation as a strategic reaction.[1, 2] Recently, progress has been made in Pd- catalyzed CÀH activation reactions in terms of substrate scope and practicality.[3, 4] However, two major obstacles prevent the broad synthetic application of CÀH- ...
