Ligand-controlled C (sp3)–H arylation and olefination in synthesis of unnatural chiral α–amino acids

…, S Li, Y Deng, H Fu, BN Laforteza, JE Spangler…

文献索引：He, Jian; Li, Suhua; Deng, Youqian; Fu, Haiyan; Laforteza, Brian N.; Spangler, Jillian E.; Homs, Anna; Yu, Jin-Quan Science, 2014 , vol. 343, # 6176 p. 1216 - 1220

全文：HTML全文

被引用次数: 161

摘要

Abstract The use of ligands to tune the reactivity and selectivity of transition metal catalysts for C (sp 3)–H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C (sp 3)–H arylation using pyridine and quinoline derivatives: The former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ...