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Synthesis and antiprotozoal activity of novel 2-{[2-(1H-imidazol-1-yl) ethyl] sulfanyl}-1H-benzimidazole derivatives

J Pérez-Villanueva, A Hernández-Campos…

文献索引:Perez-Villanueva, Jaime; Hernandez-Campos, Alicia; Yepez-Mulia, Lilian; Mendez-Cuesta, Carlos; Mendez-Lucio, Oscar; Hernandez-Luis, Francisco; Castillo, Rafael Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 14 p. 4221 - 4224

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被引用次数: 17

摘要

A series of 19 new 2-{[2-(1H-imidazol-1-yl) ethyl] sulfanyl}-1H-benzimidazole derivatives was synthesized starting from the properly substituted 1, 2-phenylendiamine. These compounds have hydrogen or methyl at position 1; while hydrogen, chlorine, ethoxy or methoxycarbonyl group is at position 5 and/or 6. The novel compounds were tested against protozoa Trichomonas vaginalis, Giardia intestinalis and Entamoeba histolytica. ...