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A 1, 4-Diphenyl-1, 2, 3-Triazole-Based β-Turn Mimic Constructed by Click Chemistry

…, X Zhao, WX Lan, C Cao, JT Liu, XK Jiang…

文献索引:Wu, Chun-Fang; Zhao, Xin; Lan, Wen-Xian; Cao, Chunyang; Liu, Jin-Tao; Jiang, Xi-Kui; Li, Zhan-Ting Journal of Organic Chemistry, 2012 , vol. 77, # 9 p. 4261 - 4270

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被引用次数: 17

摘要

A series of 1, 4-diphenyl-1, 2, 3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic and (1D and 2D) 1H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C– H··· O hydrogen-bonding formed between the triazole C-5 H atom and the two ether O atoms. Such folded structures make this 1, 4-diphenyl-1, 2, 3-triazole skeleton a good ...