Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes
SH van Rijt, AJ Hebden, T Amaresekera…
文献索引：Van Rijt, Sabine H.; Hebden, Andrew J.; Amaresekera, Thakshila; Deeth, Robert J.; Clarkson, Guy J.; Parsons, Simon; McGowan, Patrick C.; Sadler, Peter J. Journal of Medicinal Chemistry, 2009 , vol. 52, # 23 p. 7753 - 7764
We show that the binding mode adopted by picolinamide derivatives in organometallic OsII and RuII half-sandwich complexes can lead to contrasting cancer cell cytotoxicity. N-Phenyl picolinamide derivatives (XY) in OsII (1, 3− 5, 7, 9) and RuII (2, 6, 8, 10) complexes [(η6- arene)(Os/Ru)(XY) Cl] n+, where arene= p-cymene (1− 8, 10) or biphenyl (9), can act as N, N-or N, O-donors. Electron-withdrawing substituents on the phenyl ring resulted in N, N- ...
