Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators

…, TP Selby, JH Freudenberger, TM Stevenson…

文献索引：Lahm, George P.; Selby, Thomas P.; Freudenberger, John H.; Stevenson, Thomas M.; Myers, Brian J.; Seburyamo, Gilles; Smith, Ben K.; Flexner, Lindsey; Clark, Christopher E.; Cordova, Daniel Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4898 - 4906

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被引用次数: 319

摘要

A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure–activity, and biological results are presented.