Carbonic anhydrase models. 5. Tris (4, 5-di-n-propyl-2-imidazolyl) phosphine-zinc (2+) and bis (4, 5-di-isopropyl-2-imidazolyl)-2-imidazolylphosphine-zinc (2+). …
H Slebocka-Tilk, JL Cocho, Z Frackman…
文献索引：Slebocka-Tilk, H.; Cocho, J. L.; Frakman, Z.; Brown, R. S. Journal of the American Chemical Society, 1984 , vol. 106, # 8 p. 2421 - 2431
Abstract: The title trisimidazolylphosphines (4a and 5, respectively) were prepared and their Zn2+ and Co2+ complexes studied as active-site models for carbonic anhydrase. Both ligands bind Zn2+ more strongly than they do Co2+. NMR studies show that 4a. ZnC1, exists as a 1: l complex which undergoes dynamic exchange on the NMR time scale indicative of an imidazole debinding, tautomerization, and rebinding through the opposite nitrogen. 5. ...
