Methotrexate analogs. 19. Replacement of the glutamate side-chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and …

A Rosowsky, RA Forsch, JH Freisheim…

文献索引：Rosowsky, Andre; Forsch, Ronald A.; Freisheim, James H.; Moran, Richard G.; Wick, Michael Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 600 - 604

全文：HTML全文

被引用次数: 34

摘要

(AMT), l" we were interested in preparing and evaluating the biological activity of compounds in which the y-carboxyl of the glutamate moiety is replaced by another acidic group. Replacement of C02H by SOsH seemed attractive because of the ready availability ...