A series of 2 (Z)-2-benzylidene-6, 7-dihydroxybenzofuran-3 [2H]-ones as inhibitors of chorismate synthase

MG Thomas, C Lawson, NM Allanson, BW Leslie…

文献索引：Thomas, Michael G.; Lawson, Chris; Allanson, Nigel M.; Leslie, Bruce W.; Bottomley, Joanna R.; McBride, Andrew; Olusanya, Oyinkan A. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 423 - 426

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被引用次数: 26

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones was identified as potent inhibitors of bacterial chorismate synthase. The 2′-hydroxy-4′-pentoxy analogue 33 is a potent inhibitor of Streptococcus pneumoniae chorismate synthase. ... We have synthesized a series of ...