Bifunctional agents for reperfusion arrhythmias: Novel hybrid vitamin E/Class I antiarrhythmics

…, E Rekka, M Chryselis, P Papazafiri, C Gaitanaki…

文献索引：Koufaki, Maria; Calogeropoulou, Theodora; Rekka, Eleni; Chryselis, Michael; Papazafiri, Panagiota; Gaitanaki, Catherine; Makriyannis, Alexandros Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5209 - 5219

全文：HTML全文

被引用次数: 24

摘要

We have synthesized a series of hybrid compounds combining the pharmacophoric redox moieties of vitamin E and key features responsible for the antiarrhythmic properties of the class I antiarrhythmics procainamide and lidocaine. Procainamide analogue (2a) and lidocaine analogues (14a) and (14b) are very strong inhibitors of lipid peroxidation. All analogues tested at 100 or 30 μM enhanced the post ischemic recovery without inducing ...