Copper (I)-catalyzed synthesis of 2, 5-disubstituted furans and thiophenes from haloalkynes or 1, 3-diynes

H Jiang, W Zeng, Y Li, W Wu, L Huang…

文献索引：Jiang, Huanfeng; Zeng, Wei; Li, Yibiao; Wu, Wanqing; Huang, Liangbing; Fu, Wei Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5179 - 5183

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被引用次数: 66

摘要

A regioselective synthesis of 2, 5-disubstituted furans using copper (I) catalyst from haloalkynes in a one-pot procedure has been reported. This chemistry proceeds through the hydration reaction of 1, 3-diynes, which can be readily prepared from the coupling reaction of haloalkynes in the presence of CuI. The procedure also can be used for the facile synthesis of 2, 5-disubstituted thiophenes.