Enantioselective Synthesis of 3-Arylquinazolin-4 (3 H)-ones via Peptide-Catalyzed Atroposelective Bromination

…, AJ Metrano, S Kusano, SJ Miller

文献索引：Mbofana, Curren T.; Miller, Scott J. Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3285 - 3292

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被引用次数: 13

摘要

We report the development of a tertiary amine-containing β-turn peptide that catalyzes the atroposelective bromination of pharmaceutically relevant 3-arylquinazolin-4 (3 H)-ones (quinazolinones) with high levels of enantioinduction over a broad substrate scope. The