Novel tetrahydropyrido [4, 3-d] pyrimidines as gastric antilesion agents

PJ Sanfilippo, M Urbanski, L Williams, JB Press…

文献索引：Sanfilippo, PJ; Urbanski, M; Williams, L; Press, JB; Katz, LB; et al. European Journal of Medicinal Chemistry, 1992 , vol. 27, # 7 p. 655 - 661

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被引用次数: 9

摘要

Abstract A variety of substituted tetrahydropyrido [4, 3-d] pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido [4, 3-d] ...