The neurotransmitter adenosine interacts with four G-protein coupled receptors the A 1 , A 2A , A 2B and A 3 receptors. 1 The A 2A receptor, which is Gs coupled, is of particular interest in the area of psychiatry research with high receptor densities found to be located in the dopamine-rich areas of the striatum and nucleus accumbens. 2 More recently A 2A receptors have been shown to be co-localized and interact with both dopamine D 2 and ...
