Mukaiyama Aldol Reactions Catalyzed by Zirconocene Bis (triflate) Complexes: Stereochemistry and Mechanisms for CC Bond Formation

…, GV Bondar, CJ Levy, S Collins

文献索引：Lin, Shuqiong; Bondar, Georgiy V.; Levy, Christopher J.; Collins, Scott Journal of Organic Chemistry, 1998 , vol. 63, # 6 p. 1885 - 1892

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被引用次数: 23

摘要

The aldol condensations of α-and β-(benzyloxy) aldehydes with enol silanes, catalyzed by Cp2Zr (OTf) 2⊙ THF or Cp2Zr (OTf) 2, in a variety of solvents were studied. The simple diastereoselectivity of these reactions is modest and comparable to that observed using simple aldehydes of similar steric requirements. Studies have revealed that TMSOTf is directly produced on reaction with the zirconocene catalyst with the enol silane in ...