Synthesis

Coupling-Isomerization-Stetter and Coupling-Isomerization-Stetter-Paal-Knorr Sequences-A Multicomponent Approach to Furans and Pyrroles

RU Braun, TJJ Mueller

文献索引：Braun, Roland U.; Mueller, Thomas J. J. Synthesis, 2004 , # 14 p. 2391 - 2406

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被引用次数: 32

摘要

Abstract 2, 3, 5-Trisubstituted furans 6 and 1, 2, 3, 5-tetrasubstituted pyrroles 8 can be synthesized in good yields in a one-pot three-step three-or four-component process by a coupling-isomerization-Stetter-Paal-Knorr sequence of an electron-poor (hetero) aryl halide 1, a terminal propargyl alcohol 2, an aldehyde 3, and, in the case of pyrroles, a primary amine 7. All novel furans and pyrroles exhibit a strong blue fluorescence with ...