Synthesis and biological activity of azasqualenes, bis-azasqualenes and derivatives

…, G Balliano, F Viola, L Cattel, N Gerst, F Schuber

文献索引：Ceruti, Maurizio; Balliano, Gianni; Viola, Franca; Cattel, Luigi; Gerst, Nicolas; Schuber, Francis European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 199 - 208

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被引用次数: 64

摘要

Abstract Azasqualenes, bis-azasqualenes and derivatives, designed as inhibitors of squalene 2, 3-epoxide cyclase, a key enzyme in sterol biosynthesis, were synthesized and their in vitro activities against a variety of yeasts, fungi, gram-positive and gram-negative bacteria were determined.