Tetrahedron

Regiospecific synthesis of 3-(2, 6-dihydroxyphenyl) phthalides: application to the synthesis of isopestacin and cryphonectric acid

D Mal, P Pahari, SR De

文献索引：Mal, Dipakranjan; Pahari, Pallab; De, Saroj Ranjan Tetrahedron, 2007 , vol. 63, # 47 p. 11781 - 11792

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被引用次数: 34

摘要

DBU catalyzed condensation of phthalaldehydic acids and 1, 3-diketones has been developed to be a general method for the synthesis of 3-substituted phthalides. This method, in combination with mercuric acetate mediated oxidative aromatization has been utilized for the regiospecific synthesis of isopestacin (9) and cryphonectric acid (10).