Synthesis and antitumor activities of novel 1, 4-disubstituted phthalazine derivatives

…, D Chen, W Lan, Q Zhao, C Dong, L Xia, P Gong

文献索引：Zhang, Shulan; Zhao, Yanfang; Liu, Yajing; Chen, Dong; Lan, Weihuan; Zhao, Qiaoling; Dong, Chengcheng; Xia, Lin; Gong, Ping European Journal of Medicinal Chemistry, 2010 , vol. 45, # 8 p. 3504 - 3510

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被引用次数: 22

摘要

In an attempt to develop potent and selective antitumor agents, a series of novel 1, 4- disubstituted phthalazine derivatives was designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB- 231 cell lines in vitro. Among them, seven compounds (7a–7e, 7j and 7i) displayed excellent selectivity for MDA-MB-231 cells with IC50 values in the nM range, a desirable range for ...