Tetrahedron Letters

Protein kinase C modulators. Indolactams. 1. Efficient and flexible routes for the preparation of (-)-indolactam V for use in the synthesis of analogs

J Quick, B Saha, PE Driedger

文献索引：Quick, James; Saha, Bijali; Driedger, Paul E. Tetrahedron Letters, 1994 , vol. 35, # 46 p. 8549 - 8552

全文：HTML全文

被引用次数: 28

摘要

Abstract Three syntheses of the protein kinase C activator,(-)-indolactam V, are described and are compared for their potential utility in the preparation of ILV analogs. In one route the 4-amino functionality is introduced regiospecifically during the construction of the indole portion and enantiomeric control is achieved by the alkylation of the amine with a triflate derived from d-valine. One of the routes affords racemic ILV from which (-)-ILV is obtained ...