Water soluble, core-modified porphyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid- …

…, SL Gibson, R Hilf, SR Davies, AR Oseroff…

文献索引：Brennan, Nancy K.; Hall, Jonathan P.; Davies, Sherry R.; Gollnick, Sandra O.; Oseroff, Allan R.; Gibson, Scott L.; Hilf, Russell; Detty, Michael R. Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5123 - 5135

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被引用次数: 76

摘要

Water soluble, core-modified porphyrins 1-5 bearing 1-4 carboxylic acid groups were prepared and evaluated in vitro as photosensitizers for photodynamic therapy. The 21, 23- core-modified porphyrins 1-5 gave band I absorption maxima with λmax of 695-701 nm. The number of carboxylic acid groups in the dithiaporphyrins 1-4 had little effect on either absorption maxima (λmax of 696-701 nm for band I) or quantum yields of singlet oxygen ...