Thiadiazole derivatives as potential anticonvulsant agents

P Mullick, SA Khan, S Verma…

文献索引：Mullick, Pooja; Khan, Suroor A.; Verma, Surajpal; Alam, Ozair Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 3 p. 1011 - 1016

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被引用次数: 17

摘要

Abstract A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR, NMR, NMR and mass spectral data confirmed the structure of the synthesized compounds. The derivatives of these moieties were evaluated for anticonvulsant activity by MES model and neurotoxicity by rotarod method. The synthesized compounds showed ...