Enantioselective Synthesis of α??Alkyl?螃漫?ketoesters: Asymmetric Roskamp Reaction Catalyzed by an Oxazaborolidinium Ion

L Gao, BC Kang, GS Hwang…

文献索引：Gao, Lizhu; Kang, Byung Chul; Hwang, Geum-Sook; Ryu, Do Hyun Angewandte Chemie - International Edition, 2012 , vol. 51, # 33 p. 8322 - 8325

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被引用次数: 29

摘要

The Roskamp reaction,[1] a Lewis acid catalyzed reaction of alkyl diazoesters with aldehydes, is a powerful and useful synthetic method to construct β-keto carbonyl compounds, which have been utilized in the synthesis of natural products [2](Scheme 1). An asymmetric variant of this transformation was previously effected using the chiral-auxiliary- based approach with a camphorsultam-derived diazocarbonyl compound.[3a] To the best ...