2-Arylbenzothiazole, benzoxazole and benzimidazole derivatives as fluorogenic substrates for the detection of nitroreductase and aminopeptidase activity in clinically …

M Cellier, OJ Fabrega, E Fazackerley, AL James…

文献索引：Cellier, Marie; Fabrega, Olivier J.; Fazackerley, Elizabeth; James, Arthur L.; Orenga, Sylvain; Perry, John D.; Salwatura, Vindhya L.; Stanforth, Stephen P. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 9 p. 2903 - 2910

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被引用次数: 38

摘要

Abstract A series of 2-(2-nitrophenyl) benzothiazole 7, 2-(2-nitrophenyl) benzoxazole 10 and 2-(2-nitrophenyl) benzimidazole 13 derivatives have been synthesised and assessed as indicators of nitroreductase activity across a range of clinically important Gram negative and Gram positive bacteria. The majority of Gram negative bacteria produced strongly fluorescent colonies with substrates 7 and 10 whereas fluorescence production in Gram ...