Formal total synthesis of perhydrohistrionicotoxin. An organopalladium route

SA Godleski, DJ Heacock, JD Meinhart…

文献索引：Godleski, Stephen A.; Heacock, Deborah J.; Meinhart, James D.; Wallendael, Shawn Van Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 2101 - 2103

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被引用次数: 45

摘要

Members of the histrionicotoxin family of alkaloids have attracted considerable interest among synthetic chemists because of their unique structural features and their important properties as cholinolytica and modifiers of specific ion channels in nerves. lq2 Syntheses of perhydrohistrionicotoxin (1:" PHTx), a nonnaturally occurring congener of histrionicotoxin with comparable activity, and accounts describing approaches to 17+ have appeared in ...