Scheme [1] outlines the synthesis of a series of 5- or 6-substituted 2-phenyl-3H-pyrimidin-4-ones from the reactions of the enones 1a-o with benzamidine hydrochloride. In order to obtain better yields, three methods were tested (Scheme [1] ). Table [1] presents the optimized results obtained after each reaction was carried out by the three methods. It is important to mention that method A was the method of choice for most reactions, because it furnished better yields and ...
