Tetrahedron letters

Solid-phase synthesis of unsymmetrical ureas through the use of Kenner safety-catch linker

D Fattori, P D'Andrea, M Porcelloni

文献索引：Fattori, Daniela; D'Andrea, Piero; Porcelloni, Marina Tetrahedron Letters, 2003 , vol. 44, # 4 p. 811 - 814

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被引用次数: 12

摘要

A new strategy for the solid-phase synthesis of unsymmetrical ureas is described. Upon treatment of Kenner safety-catch linker with an isocyanate, followed by TMSCHN2 or iodoacetonitrile and an amine, the corresponding unsymmetrical ureas are released in solution.