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Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

TA Blizzard, F DiNinno, JD Morgan, HY Chen…

文献索引:Blizzard, Timothy A.; Dininno, Frank; Morgan II, Jerry D.; Chen, Helen Y.; Wu, Jane Y.; Kim, Seongkon; Chan, Wanda; Birzin, Elizabeth T.; Yang, Yi Tien; Pai, Lee-Yuh; Fitzgerald, Paula M.D.; Sharma, Nandini; Li, Ying; Zhang, Zhoupeng; Hayes, Edward C.; Dasilva, Carolyn A.; Tang, Wei; Rohrer, Susan P.; Schaeffer, James M.; Hammond, Milton L. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 107 - 113

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被引用次数: 43

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue. ... A series of benzoxathiin SERAMs was prepared. ...