An asymmetric synthesis of the anti-metastatic prostacyclin analogue cicaprost and a formal one of its isomer isocicaprost by a new route are described. A key step of these syntheses is the coupling of a chiral bicyclic C6-C14 ethynyl building block with a chiral C15-C21 ω-side chain amide building block with formation of the C14-C15 bond of the target molecules. A highly stereoselective reduction of the thereby obtained C6-C21 intermediate carrying a ...
![(+)-(E,3aS,4S,5R,6aS)-{[5-hydroxy-4-((3S,4S)-3-hydroxy-4-methylnona-1,6-diynyl)-hexahydropentalen-2-yliden]ethoxy}acetic acid tert-butyl ester结构式](https://image.chemsrc.com/caspic/011/597557-61-4.png)
