Input resetting control (IRC) is an economical and effective approach to achieve good closed-loop behavior for systems with extra inputs. The paper investigates use of the cascade IRC implementation in the two-input-single-output (TISO) case. The SIMC method is employed as the PI tuning rule for achieving input resetting responses with the desired robustness level. An important feature of the proposed methodology is that both of fast and slow controllers are dealt with in a unified way. Followed by obtaining a SIMC-PI fast controller with a rapid set-point tracking response, the SIMC rule is applied for designing the outer loop controller in terms of an equivalent transfer function between the two manipulated variables. Numerical simulations have been carried out on time delay processes to demonstrate the effectiveness of the proposed method. Moreover, the feasibility of implementing the proposed control strategy in practice is verified by a light intensity control experiment.