Derivatives of the potent angiotensin converting enzyme inhibitor 5 (S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: effect of changes at postions 2 and 5 of the …
1294 Journal of Medicinal Chemistry, 1982, Vol. 25, No. I1 chloride to yield methyl esters 6a or 6b. The acid chloride 15 (Scheme 11) was obtained by two different methods. In the first method, partial saponification of dimethyl methylsuccinate yielded a mixture of 12 and 13. A small amount of each of these acids was obtained pure by preparative HPLC. Both 12 and 13 were converted to their corresponding acid chlorides 14 and 15 and condensed with ...
