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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

The preparation and some chemistry of 2, 2-dimethyl-1, 2-dihydroquinolines

NM Williamson, AD Ward

文献索引：Williamson, Natalie M.; Ward, A. David Tetrahedron, 2005 , vol. 61, # 1 p. 155 - 165

全文：HTML全文

被引用次数: 23

摘要

The cyclisation of N-(1, 1-dimethylpropargyl) anilines, using cuprous chloride in refluxing toluene, yields 6-substituted-2, 2-dimethyl-1, 2-dihydroquinolines. The reactivity of the double bond in the heterocyclic ring of these products is exemplified by chlorination, to yield 6-substituted-3, 4-cis-dichloro-2, 2-dimethyl-1, 2, 3, 4-tetrahydroquinolines which can be selectively dechlorinated to provide 6-substituted-3-chloro-2, 2-dimethyl-1, 2, 3, 4- ...

2,2,6-trimethyl-1,2-dihydroquinoline结构式

2,2,6-trimethyl...

三氟乙酸酐(TFAH)结构式

三氟乙酸酐(TFAH)

~72%

2,2,2-trifluoro-1-(2,2,6-trimethylquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

N-(1,1-Dimethyl-2-propynyl)-p-toluidine结构式

N-(1,1-Dimethyl...

~%

2,2,2-trifluoro-1-(2,2,6-trimethylquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

6-methoxy-2,2-dimethyl-1H-quinoline结构式

6-methoxy-2,2-d...

三氟乙酸酐(TFAH)结构式

三氟乙酸酐(TFAH)

~42%

2,2,2-trifluoro-1-(6-methoxy-2,2-dimethylquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

未登录结构式

~%

2,2,2-trifluoro-1-(6-methoxy-2,2-dimethylquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

1-acetyl-2,2,6-trimethyl-1,2-dihydroquinoline结构式

1-acetyl-2,2,6-...

~14%

1-(4-hydroxy-2,2,6-trimethyl-3,4-dihydroquinolin-1-yl)ethanone结构式

1-(4-hydroxy-2,...

2,2,6-trimethyl-1,2-dihydroquinoline结构式

2,2,6-trimethyl...

~%

1-(4-hydroxy-2,2,6-trimethyl-3,4-dihydroquinolin-1-yl)ethanone结构式

1-(4-hydroxy-2,...

N-(1,1-Dimethyl-2-propynyl)-p-toluidine结构式

N-(1,1-Dimethyl...

~%

1-(4-hydroxy-2,2,6-trimethyl-3,4-dihydroquinolin-1-yl)ethanone结构式

1-(4-hydroxy-2,...

2,2,6-trimethyl-1,2-dihydroquinoline结构式

2,2,6-trimethyl...

~%

1-(3-chloro-2,2,6-trimethylquinolin-1-yl)ethanone结构式

1-(3-chloro-2,2...

N-(1,1-Dimethyl-2-propynyl)-p-toluidine结构式

N-(1,1-Dimethyl...

~%

1-(3-chloro-2,2,6-trimethylquinolin-1-yl)ethanone结构式

1-(3-chloro-2,2...

1-acetyl-2,2,6-trimethyl-1,2-dihydroquinoline结构式

1-acetyl-2,2,6-...

~%

1-(3-chloro-2,2,6-trimethylquinolin-1-yl)ethanone结构式

1-(3-chloro-2,2...

6-bromo-2,2-dimethyl-1,2-dihydroquinoline结构式

6-bromo-2,2-dim...

三氟乙酸酐(TFAH)结构式

三氟乙酸酐(TFAH)

~88%

1-(6-bromo-2,2-dimethylquinolin-1-yl)-2,2,2-trifluoroethanone结构式

1-(6-bromo-2,2-...

4-bromo-N-(2-methylbut-3-yn-2-yl)benzenamine结构式

4-bromo-N-(2-me...

~%

1-(6-bromo-2,2-dimethylquinolin-1-yl)-2,2,2-trifluoroethanone结构式

1-(6-bromo-2,2-...

未登录结构式

三氟乙酸酐(TFAH)结构式

三氟乙酸酐(TFAH)

~86%

2,2,2-trifluoro-1-(6-hydroxy-2,2-dimethylquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

N-(2,2-dimethyl-1,2-dihydro-6-quinolyl)acetamide结构式

N-(2,2-dimethyl...

三氟乙酸酐(TFAH)结构式

三氟乙酸酐(TFAH)

~49%

N-[2,2-dimethyl-1-(2,2,2-trifluoroacetyl)quinolin-6-yl]acetamide结构式

N-[2,2-dimethyl...

ethyl 4-(1,1-dimethyl-2-propynylamino)phenylacetate结构式

ethyl 4-(1,1-di...

~55%

ethyl 2-(2,2-dimethyl-1H-quinolin-6-yl)acetate结构式

ethyl 2-(2,2-di...

2,2-二甲基-1,2-二氢喹啉结构式

2,2-二甲基-1,2-二氢喹啉

三氟乙酸酐(TFAH)结构式

三氟乙酸酐(TFAH)

~67%

1-(2,2-dimethylquinolin-1-yl)-2,2,2-trifluoroethanone结构式

1-(2,2-dimethyl...

未登录结构式

三氟乙酸酐(TFAH)结构式

三氟乙酸酐(TFAH)

~%

1-(2,2-dimethylquinolin-1-yl)-2,2,2-trifluoroethanone结构式

1-(2,2-dimethyl...

6-iodo-2,2-dimethyl-1,2-dihydroquinoline结构式

6-iodo-2,2-dime...

三氟乙酸酐(TFAH)结构式

三氟乙酸酐(TFAH)

~74%

2,2,2-trifluoro-1-(6-iodo-2,2-dimethylquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

3,4-epoxy-1-trifluoroacetyl-2,2,6-trimethyl-1,2,3,4-tetrahydroquinoline结构式

3,4-epoxy-1-tri...

~69%

2,2,2-trifluoro-1-(3-hydroxy-2,2,6-trimethyl-3,4-dihydroquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

2,2,6-trimethyl-1,2-dihydroquinoline结构式

2,2,6-trimethyl...

~%

2,2,2-trifluoro-1-(3-hydroxy-2,2,6-trimethyl-3,4-dihydroquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

N-(1,1-Dimethyl-2-propynyl)-p-toluidine结构式

N-(1,1-Dimethyl...

~%

2,2,2-trifluoro-1-(3-hydroxy-2,2,6-trimethyl-3,4-dihydroquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

2,2,2-trifluoro-1-(2,2,6-trimethylquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...

~%

2,2,2-trifluoro-1-(3-hydroxy-2,2,6-trimethyl-3,4-dihydroquinolin-1-yl)ethanone结构式

2,2,2-trifluoro...