Recent advances in radical-based C–N bond formation via photo-/electrochemistry
Yating Zhao, Wujiong Xia
文献索引：10.1039/C7CS00572E
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摘要
The employment of nitrogen sources with free N–H bonds for amination is considered to be most straightforward and desirable, especially when the C–N bonds are prepared from N–H bonds and non-functionalized carbon sources, such as C–H bonds and C–C double/triple bonds, since this obviates the needs for the pre-installation of reactive groups in the starting materials and leads to a high atom and step economy. Recently, radical chemistry has been resuscitated owing to its great value in organic synthesis, and notable advances have been made in the direct use of N–H bonds for radical-based C–N bond formation with photo-/electrotechniques. Apart from the well-studied N-radical species addition pathway, radical-mediated aminations also proceed through N-atom nucleophilic addition, C-/N-radical cross-coupling, and a hydrogen-atom transfer (HAT) process. This review highlights the recent advances in this area with emphasis on the related reaction mechanisms.