Abstract Various N [(p-substituted/unsubstituted) phenyl),(substituted thiazol-2-yl/oxazol-2- yl/naphthothiazol-2-yl)], N'-[N"', N"'-dimethyl/diethylaminoacetyl], N"-phenyl guanidines were prepared from corresponding N-substituted thiocarbamides and were evaluated for their antiinflammatory activity. All the substituted guanidines (100 mg/Kg) provided 1-79% protection against carrageenin induced edema in rats. Phenyl butazone (100 mg/Kg) was ...
